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pentobarbital will lessen the extent or effect of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Potent or moderate CYP3A4 inducers significantly lower guanfacine plasma concentrations and elimination 50 %-lifestyle.pentobarbital will decrease the extent or influence of sildenafil by affe